Principal Investigator

Evangelos K. Oikonomou, MD, DPhil, is a cardiologist, data scientist, and Assistant Professor of Medicine in the Section of Cardiovascular Medicine at Yale School of Medicine. He develops and clinically evaluates AI-enabled digital biomarkers from echocardiography, CT, ECG, and longitudinal health records to improve cardiovascular screening, phenotyping, risk prediction, and treatment selection. He is Deputy Editor of the European Heart Journal and Associate Director of the Yale Cardiovascular Data Science (CarDS) Lab.

Dr. Oikonomou received his MD as valedictorian from the University of Athens and his DPhil in Medical Sciences from the University of Oxford before completing the Yale Physician-Scientist Training Program in Internal Medicine and Cardiovascular Medicine. His independent research is supported by the NIH/NHLBI K23 award TARGET-TTR, which evaluates targeted AI-driven screening for transthyretin amyloid cardiomyopathy in the electronic health record. Additional support includes awards from the American Heart Association, Wellcome Leap, the Robert A. Winn Excellence in Clinical Trials Program, and the Claude D. Pepper Older Americans Independence Center; his prior training was supported by an NIH/NHLBI F32 award.

His research program spans multimodal screening strategies for underdiagnosed cardiomyopathies, including ATTR-CM through the NIH/NHLBI K23 TARGET-TTR program and HCM through the American Heart Association TARGET-HCM Career Development Award. He also evaluates digital biomarkers in cardiometabolic disease to dissect the adipose-heart-liver axis; develops digital phenotypes of valvular heart disease through the Yale Pepper Scholar Award; and studies how these tools can improve clinical-trial enrollment and care delivery through the Robert A. Winn Excellence in Clinical Trials Award. His work has appeared in The Lancet, JAMA, NEJM AI, European Heart Journal, JACC, and Circulation.